Systemic Lupus Erythematosus Epidemiology

It can affect the joints skin brain lungs kidneys and blood vessels. Due to improved detection of mild disease the incidence nearly tripled in the last 40 years of the 20 th century 4. In the early 21st century systemic lupus erythematosus sle is recognised as a chronic often severe autoimmune rheumatic disease that affects people worldwide with the evolution of immunological understanding including the recognition of the antinuclear factor and the development of american college of rheumatology criteria for the classification of lupus more studies have been carried out allowing a deeper understanding of occurrence epidemiology and risk factors.

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Systemic lupus erythematosus sle is a disease of multifactorial etiology.

Systemic lupus erythematosus epidemiology. Sle is an autoimmune disease in which the immune system attacks its own tissues causing widespread inflammation and tissue damage in the affected organs. Systemic lupus erythematosus sle or lupus is a complex and severe rheumatic disease with exceedingly diverse clinical manifestations. The epidemiology of systemic lupus erythematosus. Rees f 1 2 doherty m 1 grainge mj 3 lanyon p 1 2 zhang w 1.

Epidemiologic features of diffuse connective tissue disorders in rochester minn 1951 through 1967 with special reference to systemic lupus erythematosus. Quantifying the burden of sle across different countries can clarify the role of genetic environmental and other causative factors in the natural history of the disease and to understand its clinical and societal consequences. Systemic lupus erythematosus sle is a disease distributed worldwide which occurs in both genders and across racial ethnic and age groups. The worldwide incidence and prevalence of systemic lupus erythematosus.

However higher rates are observed in adults in women and in non caucasians. 1 division of rheumatology orthopaedics and dermatology university of nottingham. In women prevalence rates vary from 164 white to 406 african american per 100 000 2. Systemic lupus erythematosus sle is the most common type of lupus.

Systemic lupus erythematosus sle is the prototypical systemic autoimmune disease with a significant disease burden across the world among different ethnic racial and age groups. A systematic review of epidemiological studies. Kurland lt hauser wa ferguson rh holley ke. The reported prevalence of systemic lupus erythematosus sle in the united states is 20 to 150 cases per 100 000 1 3.