Systemic Lupus Erythematosus Sle Mechanism
Clinically in sle patients we see flares period of illness and remissions recovery.
Systemic lupus erythematosus sle mechanism. To understand the mechanisms that regulate these interactions and the processes responsible for an immune system that is increasingly autoreactive it is essential to definitively control lupus and related disorders. More than 90 of cases of sle occur in women frequently starting at childbearing age. Lupus technically known as systemic lupus erythematosus sle is an autoimmune disease in which the body s immune system mistakenly attacks healthy tissue in many parts of the body. Sle is involved in bothe type 2 and type 3 hypersensitivity.
Hydroxychloroquine in systemic lupus erythematosus sle article pdf available in expert opinion on drug safety 16 3 december 2016 with 1 513 reads how we measure reads. Figure 2 manhattan plot of a genome wide association study gwas in systemic lupus erythematosus sle involving 1311 cases and 3340 controls of european ancestry. Epigenetic mechanisms may represent the missing link between genetic and environmental risk factors. Systemic lupus erythematosus sle is a chronic inflammatory disease that has protean manifestations and follows a relapsing and remitting course.
The immune complexes form when autoantibodies are made against the nucleic acids and protein constituents of the nucleus of cells. This editorial provides a synopsis of newly discovered genetic factors and signaling pathways in lupus pathogenesis that are documented in 11 state of the art reviews and original articles. We ll show you photos to help you identify your. Pathogenic mechanisms in systemic lupus erythematosus.
The exact mechanism by which this occurs is not yet clear. Download the slides and related material from. Polymorphonuclear cells in systemic lupus erythematosus a neutrophil specific gene expression signature was reported to correlate positively with sle disease activity in patients with sle suggesting that these cells may play an important role in sle pathogenesis. Systemic lupus erythematosus sle is a chronic inflammatory diseasecharacterized by the dysfunction of t cells b cells and dendritic cells and by the production of antinuclear autoantibodies.
Systemic lupus erythematosus sle is a complex disease caused by complex interactions between genes and the environment sex age hormones smoking infections drugs and abnormalities of both the innate and adaptive immune systems.
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